--- a/README.markdown Thu Jan 23 23:59:44 2020 -0500
+++ b/README.markdown Fri Jan 24 00:00:38 2020 -0500
@@ -174,12 +174,12 @@
1. Average density would be `(/ 3r4 3r9) = 1/100000` or 1 gene every ~100kb.
2. Parts:
- A. Two humans would have roughly 250k differences.
- B. A human and a chimpanzee would have roughly 3m differences.
+ * A: Two humans would have roughly 250k differences.
+ * B: A human and a chimpanzee would have roughly 3m differences.
3. Parts:
- A. Average density would be 2 SNPs per 1000 base pairs.
- B. Is this a trick question? I think 1.1% of the differences would be in protein-coding regions.
+ * A: Average density would be 2 SNPs per 1000 base pairs.
+ * B: Is this a trick question? I think 1.1% of the differences would be in protein-coding regions.
4. Parts:
- A. I am confused. The glossary defines a "haplotype" as a group of closely-linked genes that are typically inherited together. So… 1 haplotype? But the *text* talks about a haplotype as being a combination of SNPs in a recombination-poor region. So if "haplotype" means the combination of SNPs, not a set of genes, then I think this would be `4^10 = 1048576`.
- B. On a diploid chromosome, you'd have two separate sets of SNPs to combine (and order doesn't matter), so I think it's `4^10 * 4^10 / 2`.
- C. `(1 SNP / 5 kb) * (100 kb) = 20 SNPs = 2^20 sequences = 1048576 sequences`
+ * A: I am confused. The glossary defines a "haplotype" as a group of closely-linked genes that are typically inherited together. So… 1 haplotype? But the *text* talks about a haplotype as being a combination of SNPs in a recombination-poor region. So if "haplotype" means the combination of SNPs, not a set of genes, then I think this would be `4^10 = 1048576`.
+ * B: On a diploid chromosome, you'd have two separate sets of SNPs to combine (and order doesn't matter), so I think it's `4^10 * 4^10 / 2`.
+ * C: `(1 SNP / 5 kb) * (100 kb) = 20 SNPs = 2^20 sequences = 1048576 sequences`