# HG changeset patch # User Steve Losh # Date 1579842038 18000 # Node ID 9c12f5e69d34ba2b6f50c20409570068b4531a2e # Parent ff3116e5eac28a9e645c01613b982b51ca88e437 Update diff -r ff3116e5eac2 -r 9c12f5e69d34 README.markdown --- a/README.markdown Thu Jan 23 23:59:44 2020 -0500 +++ b/README.markdown Fri Jan 24 00:00:38 2020 -0500 @@ -174,12 +174,12 @@ 1. Average density would be `(/ 3r4 3r9) = 1/100000` or 1 gene every ~100kb. 2. Parts: - A. Two humans would have roughly 250k differences. - B. A human and a chimpanzee would have roughly 3m differences. + * A: Two humans would have roughly 250k differences. + * B: A human and a chimpanzee would have roughly 3m differences. 3. Parts: - A. Average density would be 2 SNPs per 1000 base pairs. - B. Is this a trick question? I think 1.1% of the differences would be in protein-coding regions. + * A: Average density would be 2 SNPs per 1000 base pairs. + * B: Is this a trick question? I think 1.1% of the differences would be in protein-coding regions. 4. Parts: - A. I am confused. The glossary defines a "haplotype" as a group of closely-linked genes that are typically inherited together. So… 1 haplotype? But the *text* talks about a haplotype as being a combination of SNPs in a recombination-poor region. So if "haplotype" means the combination of SNPs, not a set of genes, then I think this would be `4^10 = 1048576`. - B. On a diploid chromosome, you'd have two separate sets of SNPs to combine (and order doesn't matter), so I think it's `4^10 * 4^10 / 2`. - C. `(1 SNP / 5 kb) * (100 kb) = 20 SNPs = 2^20 sequences = 1048576 sequences` + * A: I am confused. The glossary defines a "haplotype" as a group of closely-linked genes that are typically inherited together. So… 1 haplotype? But the *text* talks about a haplotype as being a combination of SNPs in a recombination-poor region. So if "haplotype" means the combination of SNPs, not a set of genes, then I think this would be `4^10 = 1048576`. + * B: On a diploid chromosome, you'd have two separate sets of SNPs to combine (and order doesn't matter), so I think it's `4^10 * 4^10 / 2`. + * C: `(1 SNP / 5 kb) * (100 kb) = 20 SNPs = 2^20 sequences = 1048576 sequences`