SETO
author |
Steve Losh <steve@stevelosh.com> |
date |
Fri, 20 Dec 2019 17:12:23 -0500 |
parents |
474d88a2af2e |
children |
2735aa6aab79 |
(in-package :rosalind)
;; When a heterozygous organism mates, its offspring have a 50% chance to be
;; heterozygous themselves, *regardless of what the other mate happens to be*:
;;
;; A a A a A a
;; A AA Aa A AA Aa a aA aa
;; A AA Aa a Aa aa a aA aa
;;
;; Because everyone breeds with an Aa Bb mate, we don't need to worry about
;; tracking populations along the way. Every child has a 1/2 chance of being
;; Aa, and likewise a 1/2 chance of being Bb.
;;
;; Because A's and B's are independent, this means there's a 1/2 * 1/2 = 1/4
;; chance of any given child being Aa Bb.
(defun bernoulli-exactly (successes trials success-probability)
"Return the probability of exactly `successes` in `trials` Bernoulli trials.
Returns the probability of getting exactly `n` successes out of `trials`
Bernoulli trials with `success-probability`.
"
;; For a group of N trials with success/failure probabilities s/f, any given
;; ordering of exactly S successes and F failures will have probability:
;;
;; s * s * s * … * f * f * f
;;
;; There are N choose S possible orderings (or N choose F, it doesn't matter),
;; so we just sum up the probabilities of all of them.
(let ((failures (- trials successes))
(failure-probability (- 1 success-probability)))
(* (binomial-coefficient trials successes)
(expt success-probability successes)
(expt failure-probability failures))))
(defun bernoulli-at-least (successes trials success-probability)
"Return the probability of at least `successes` in `trials` Bernoulli trials.
Returns the probability of getting at least `n` successes out of `trials`
Bernoulli trials with `success-probability`.
"
;; P(≥S) = P(=S) + P(=S+1) + … + P(N)
(Σ (n successes trials)
(bernoulli-exactly n trials success-probability)))
(define-problem lia (data stream)
"2 1"
"0.684"
(let* ((generations (read data))
(target (read data))
(population (expt 2 generations)))
(float-string (bernoulli-at-least target population 1/4))))