--- a/README.markdown Fri Jan 17 22:09:06 2020 -0500
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@@ -53,3 +53,37 @@
Still need to figure out how to get a decent Vim setup remotely. Syncing all my
plugins is probably not ideal, but maybe. Who knows.
+
+## 2020-01-18
+
+KA biology and coffee.
+
+Cellular respiration:
+
+* Starts with glucose (C₆H₁₂O₆).
+* The process is called glycolysis, and starts in the cytosol.
+* Glycolysis split the 6-carbon glucose into two 3-carbon molecules (pyruvate).
+* In the process we produce 2 (net) ATP's, and reduce 2 NAD⁺ molecules to 2 NADH
+ (note the move from a positive charge to negative, i.e. gaining electrons,
+ i.e. RIG (reduction is gaining)).
+* Some organisms stop here and use the pyruvates for fermentation.
+* Otherwise, the carboxyl group is stripped from each pyruvate and released as
+ CO₂.
+* The rest of the pyruvate (essentially an acetyl group) latches onto "coenzyme
+ A" (aka "CoA"), forming acetyl-CoA.
+* The enzyme transfers the acetyl group to an oxaloacetic acid, which forms
+ citric acid.
+* Next step is the "Krebs cycle"/"citric acid cycle", which is… complicated, and
+ happens in the matrix of the mitochondria.
+* As the citric acid cycle progresses we keep reducing to NADH.
+* The ATPs produced in cellular respiration can be used directly.
+* The reduced NADHs (and other products like QH₂) are used to create a proton
+ gradient in the mitochondria, which is then used to produce more ATP (each
+ NADH results in ~2-3 ATPs). This happens in the crista of the mitochondria.
+* Whole result is ~27-38 ATPs (typically 29-30 in most cells).
+* Review: the four steps of cellular respiration:
+ 1. Glycolysis: splits glucose into two pyruvates, produces ATP and reduces NAD⁺ to NADH. Happens in the cytosol.
+ 2. Pyruvate Oxidation: each pyruvate is stripped of CO₂, binds to CoA, and generates more NADH.
+ 3. Citric Acid/Krebs Cycle: each acetyl-CoA goes through a cycle and produces ATP, NADH, and FADH₂.
+ 4. Oxidative Phosphorylation: the NADH and FADH₂ are used to make a proton gradient, and that is used to make more ATP.
+